蒋庆华（教授）的个人简介
蒋庆华，博士，教授，博士生导师。
主要研究方向：生物信息学。2010年6月在哈工大计算机科学与技术学科获得博士学位， 受国家留学基金委资助，2011年11月至2012年11月，公派至哈佛大学Dana-Farber癌症研究所从事生物信息学研究工作，2012年入选“哈尔滨工业大学基础研究杰出人才培育计划III类”，2015年入选哈工大青年拔尖人才选聘计划。
主持国家自然科学面上项目、青年基金、中国博士后科学基金特别资助、中国博士后基金一等资助等科研项目7项。发表SCI论文35篇，EI论文2篇。 其中第一作者或通讯作者SCI论文19篇，单篇SCI最高影响因子9.9、单篇SCI最高他引522次（google scholar统计），2010年入选“中国百篇最具影响国际学术论文”，2011年获“第十二届黑龙江省自然科学技术学术成果一等奖”。
学术兼职
《Nucleic Acids Research》、《Bioinformatics》、《Briefings in Bioinformatics》、《Scientific Reports》、 《Current Bioinformatics》、《Animal Genetics》、《International Journal of Data Mining and Bioinformatics (IJDMB)》等期刊审稿人《Austin Journal of Computational Biology and Bioinformatics》期刊编委 （2014-)《Austin Medical Sciences》期刊编委 （2015-)教育与工作经历
教育经历 1999.09-2003.07 吉林大学 计算数学 学士2003.09-2006.07吉林大学计算数学 硕士2007.03-2010.06哈尔滨工业大学计算机应用技术 博士工作履历 2010.08-2012.12 哈尔滨工业大学 生物医学工程研究中心 讲师2011.11-2012.11 哈佛大学 Dana Farber癌症研究所 访问学者2013.12-2015.12 哈尔滨工业大学 生物医学工程研究中心 副教授2015.04-至今 哈尔滨工业大学 生命科学与技术学院 博士生导师2016.01-至今 哈尔滨工业大学 生物医学工程研究中心 教授研究方向 生物信息学、癌表观基因组学：发展信息学方法，对高通量组学及临床数据进行整合及分析，研究癌症发生、发展过程中表观及转录调控机制，计算预测、实验验证癌症相关的非编码基因（lncRNA、microRNA）。基于单核苷酸多态的阿尔斯海默病（AD）遗传标记的识别与检测：构建中国或者亚洲人群AD遗传标记（SNP）知识库系统，研发疾病预测模型和算法，预测AD疾病风险。长链非编码RNA(long non-coding RNA, lncRNA)综合分析平台：发展生物信息学方法，重点研究lncRNA转录调控、功能注释及疾病lncRNA识别技术，开发集数据中心、分析平台、知识库于一体的lncRNA分析系统，推动在基因组范围内对lncRNA调控机制及功能的理解。肿瘤诊断与治疗：基于肿瘤基因组数据，发展肿瘤相关的遗传变异识别及功能注释方法， 基于变异与靶向药物的关系信息，制定个体化用药指导方案。健康管理：通过分析健康个体的基因组数据，预测潜在的疾病风险、制定个体化用药指导及健康生活方案。项目与获奖
主持的科研项目 2016.1-2019.12，国家自然科学基金面上项目2016.1-2019.12，哈工大青年拔尖人才选聘计划项目2016.1-2017.12, 黑龙江省自然科学基金面上项目2016.1-2016.12，黑龙江省留学人员择优资助项目2012.7-2015.06，哈工大基础研究杰出人才培育计划III2012.1-2014.12，国家自然科学青年基金2012.9-2014.12，中国博士后第五批特别资助基金2011.7-2013.12，中国博士后科学基金（一等资助）2011.1-2012.12，哈工大科研创新基金2012.1-2013.12，黑龙江省博士后基金参与的科研项目 2010.01-2012.12，国家自然科学基金， 排名：9/22014.01-2017.12，国家自然科学基金， 排名：8/22012.01-2015.12，国家863项目， 排名：17/112015.01-2017.12，国家863重大项目，排名18/69荣誉称号 2010年 获“中国百篇最具影响国际学术论文”2011年 获”第十二届黑龙江省自然科学技术学术成果一等奖"2012年 入选“哈尔滨工业大学基础研究杰出人才培育计划III”2015年 入选“哈尔滨工业大学青年拔尖人才选聘计划”代表性学术论文
2016 Guiyou Liu,Qinghua Jiang*. Alzheimer’s disease CD33 rs3865444 variant does not contribute to congnitive performance. 2016. PNAS. DOI: 10.1073/pnas.1600852113 (SCI IF: 9.674) (*通讯作者）Guiyou Liu,Qinghua Jiang, Yongshuai Jiang, Keshen Li. Junwei Hao*. Ischaemic stroke variants from genome-wide association studies and Alzheimeru2019s disease susceptibility. Annals of Neurology. 2016. (SCI IF: 9.977) (Accepted)Qinghua Jiang, Guiyou Liu*. Lack of association between MC1R variants and Parkinsonu2019s disease in European descent. 2016. Annals of Neurology. DOI: 10.1002/ana.24627 (SCI IF: 9.977)Qinghua Jiang, Guiyou Liu*. REST rs3796529 variant does not influence human subcortical brain structures. Annals of Neurology. 2016 Feb;79(2):334-5. (SCI IF: 9.977)Qinghua Jiang#, Shuilin Jin#, Yongshuai Jiang, Mingzhi Liao, Rennan Feng,Liangcai Zhang, Guiyou Liu*, Junwei Hao*. Alzheimer’s disease variants with the genome-wide significance are significantly enriched in immune pathways and active in immune cells. 2016. doi:10.1007/s12035-015-9670-8. Molecular Neurobiology. (SCI, IF: 5.137)Guiyou Liu#, Yining Xu#, Yongshuai Jiang, Mingzhi Liao, Rennan Feng,Qinghua Jiang*. PICALM rs3851179 variant confers susceptibility to Alzheimer’s disease in Chinese population. 2016. Molecular Neurobiology. (SCI, IF: 5.137) (Accepted) (*通讯作者）Yining Xu,Qinghua Jiang, Guiyou Liu*. PICALM rs3851179 variant and Alzheimer’s disease in Asian population. 2016. NeuroMolecular Medicine. (SCI, IF: 3.678) (Accepted)Weiyang Bai, Wen Yang, Wenjing Wang, Yang Wang, Can Liu,Qinghua Jiang, Jinlian Hua, Mingzhi Liao*. GED: a manually curated comprehensive resource for epigenetic modification of gametogenesis. Briefings in Bioinformatics. 2016 Feb 5. pii: bbw007. (SCI, IF: 9.617)2015 Jiang QH, Wang JX, Wu XL, Ma R, Jin SL, Han ZJ, Tan RJ, Peng JJ, Liu GY, Li Y, Wang YD*. LncRNA2Target: a database for differentially expressed genes after lncRNA knockdown or overexpression. 2015. Nucleic Acids Research. DOI 10.1093/nar/gku1173 (SCI, IF: 9.112)Jiang QH, Ma R, Wang JX, Wu XL, Jin SL, Peng JJ, Tan RJ, Zhang TJ, Li Y, Wang YD*. LncRNA2Function: a comprehensive resource for functional investigation of human lncRNAs based on RNA-seq data. 2015. BMC genomics. 16(s3):s2. (SCI, IF: 3.986)Han ZJ,Jiang QH*, Zhang TJ, Wu XL, Ma R, Wang JX, Bai Y, Wang RJ, Tan RJ, Wang YD*. Analyzing large-scale samples confirms the association between the rs1051730 polymorphism and lung cancer susceptibility. 2015. Scientific Reports. (Accepted) (SCI, IF: 5.578) (*通讯作者）Zhang SY, Li X, Ma G, Jiang YS, Liao MZ, Feng RN, Zhang LC, Liu JF, Wang GY, Zhao B,Jiang QH*, Li KS*, Liu GY*. CLU rs9331888 Polymorphism Contributes to Alzheimer’s Disease Susceptibility in Caucasian But Not East Asian Populations. 2015. Molecular Neurobiology, 53(3), 1446-1451. (*通讯作者) (SCI, IF: 5.137)Li YN, Song DJ, Jiang YS, Wang J, Feng R, Zhang LC, Wang GY, Chen ZG, Wang RZ*,Jiang QH*, Liu GY*. CR1 rs3818361 Polymorphism Contributes to Alzheimer’s Disease Susceptibility in Chinese Population. Molecular Neurobiology. 2015 July 21. [Epub ahead of print]. (*通讯作者) (SCI, IF: 5.137)Li KS,Jiang QH, Xu AD, Liu GY. REST rs3796529 variant does not confer susceptibility to Alzheimer’s disease. Annals of Neurology. 2015 Aug 18. doi: 10.1002/ana.24503. [Epub ahead of print] (SCI IF: 9.977)Guiyou Liu, Yongquan Liu,Qinghua Jiang, Yongshuai Jiang, Rennan Feng, Liangcai Zhang, Zugen Chen, Keshen Li , Jiafeng Liu. Convergent Genetic and Expression Datasets Highlight TREM2 in Parkinsonu2019s Disease Susceptibility. Molecular Neurobiology. 2015. DOI 10.1007/s12035-015-9416-7. (SCI, IF: 5.137)Bai Y, Ji SF,Jiang QH, Wang YD. Identification exon skipping events from high-throughput RNA sequencing data. IEEE Transactions on NanoBioscience. 2015 Jul;14(5):562-9 (SCI IF: 2.309)Xinjie Bao, Gengfeng Chen, Yongshuai Jiang,Qinghua Jiang, Mingzhi Liao, Rennan Feng, LiangcaiZhang, Guoda Ma, Shuyan Zhang, Zugen Chen, Bin Zhao, Renzhi Wang*, Keshen Li*, Guiyou Liu*. Cell adhesion molecules pathways genes are regulated by cis-regulatory SNPs and show significantly altered expression in Alzheimeru2019s disease brains. Neurobiol Aging. 2015 Jun 12 (SCI, IF: 5.013)Xiao Zhu, Henry C.M. Leung, Rongjie Wang, Francis Y.L. Chin, Siu Ming Yiu, Guangri Quan, Yajie Li, Rui Zhang,Qinghua Jiang, Bo Liu, Yucui Dong, Guohui Zhou, Yadong Wang. misFinder: Identify mis-assemblies in an unbiased manner using reference and paired-end reads. BMC Bioinformatics. 2015 (Accepted) (SCI IF: 2.44)Peng JJ, Li HX, Liu YZ, Juan LR,Jiang QH, Wang YD*. InteGO2: a web tool for measuring and visualizing gene semantic similarities using Gene Ontology. BMC Bioinformatics. 2015 (Accepted) (SCI, IF: 2.576)Zhu X, Leung HC, Wang R, Chin FY, Yiu SM, Quan G, Li Y, Zhang R,Jiang Q, Liu B, Dong Y, Zhou G, Wang Y. misFinder: identify mis-assemblies in an unbiased manner using reference and paired-end reads. BMC Bioinformatics. 2015 Nov 16;16(1):386 (SCI, IF: 2.576)2014 Jiang QH, Wang JX, Wu XL, Ma R, Jin SL, Han ZJ, Tan RJ, Peng JJ, Liu GY, Li Y, Wang YD. LncRNA2Target: a database for differentially expressed genes after lncRNA knockdown or overexpression. 2014.Nucleic Acids Research. DOI 10.1093/nar/gku1173 (SCI,IF: 8.808)Quan BK, Qi XS, Yu ZH, Jiang YS, Liao MZ, Wang GY, Feng RN, Zhang LC, Chen ZG,Jiang QH*, Liu GY*. Pathway analysis of genome-wide association study and transcriptome data highlights new biological pathways in colorectal cancer. 2014.Molecular Genetics and Genomics. DOI 10.1007/s00438-014-0945-y. (*通讯作者) (SCI,IF: 2.831)Liu GY, Bao XJ, Jiang Y,S Liao MZ,Jiang QH, Feng RN, Zhang LC, Ma GD, Chen ZG, Wang GY, Wang RZ, Zhao B, Li KS.Identifying the Association Between Alzheimer’s Disease and Parkinson’s Disease Using Genome-Wide Association Studies and Protein-Protein Interaction Network. 2014.Molecular Neurobiology. DOI 10.1007/s12035-014-8946-8 (SCI,IF=5.286)Li X, Shen N, Zhang SY, Liu JF,Jiang QH, Liao MZ, Feng RN, Zhang LC, Wang GY, Ma GD, Zhou HH, Chen ZG, Jiang YS*, Zhao B*, Li KS*, Liu GY* (2014) CD33 rs3865444 polymorphism contributes to Alzheimeru2019s disease susceptibility in European and North American but not Asian populations.Molecular Neurobiology. DOI 10.1007/s12035-014-8880-9 (SCI,IF=5.286)Xiang ZM, Xu ML, Liao MZ, Jiang YS,Jiang QH, Feng RN, Zhang LC, Ma GD, Wang GY, Chen ZG, Zhao B, Sun TS*, Li KS*, Liu GY* (2014) Integrating genome-wide association study and brain expression data highlights cell adhesion molecules and purine metabolism in Alzheimeru2019s disease.Molecular Neurobiology. DOI 10.1007/s12035-014-8884-5 (SCI,IF=5.286)Peng JJ, Li HX,Jiang QH, Wang YD, Chen J. TITLE: An Integrative Approach for Measuring Semantic Similarities using Gene Ontology.BMC systems biology. 2014, 8 (Suppl 5): S8 (SCI,IF: 2.853)Tan RJ, Wang YD, Kleinstein S, Liu YZ, Zhu XL,Jiang QH, Zhu MF. An Evaluation of Copy Number Variation Detection Tools from Whole-Exome Sequencing Data.Human mutation.2014 Mar 5. doi: 10.1002/humu.22537. [Epub 2014 May 1] (SCI,IF: 5.213)Jin SL, Tan RJ,Jiang QH, Xu L, Peng JJ, Wang Y, Wang YD. A generalized topological entropy for analyzing the complexity of DNA sequences.PLoS One. 2014 Feb 12;9(2):e88519 (SCI,IF: 3.73)Jiang QH, Wang JX, Wang YD, Ma R, Wu XL, Li Y. TF2LncRNA: Identifying common transcription factors for a list of lncRNA genes from ChIP-Seq data.BioMed Research International. vol. 2014, Article ID 317642, 5 pages, 2014. doi:10.1155/2014/317642 (SCI,IF: 2.706)2013 Jiang QH, Wang GH, Li Y, Jin SL, Wang YD. Predicting Human microRNA-disease Associations Based on Support Vector Machine. International Journal of Data Mining and Bioinformatics. 2013.vol.8, No.3. 282-2392012 Jin SL, Xu L,Jiang QH*, Duan GR. A Joint Spectral Characterization of C* Independence. Infinite Dimensional Analysis Quantum Probability and Related Topics. Vol. 15, No. 2 (2012) 1250013:1-5 ( *通讯作者)Jin SL, Jiang QH*, Wang YD*, Duan GR. On joint spectrum of infinite direct sums. Operators and Matrices. Vol. 6, No. 3 (2012), 529u2013533 ( *通讯作者)Jin SL, Xu L, Jiang QH* and L Li*. Conditions equivalent to C* independence, Studia Math. 2012,211, 191-197 ( *通讯作者)Jin SL, Xu L, Jiang QH. Joint Spectrum and Joint Distribution. Complex analysis and operator theory. 2012. DOI 10.1007/s11785-012-0258-22011 Zhu SJ, Jiang QH, Wang GH, Liu B, Teng MX, Wang YD. Chromatin structure characteristics of pre-miRNA genomic sequences. BMC genomics.2011. 12(1):329.2010 Jiang QH, Hao YY, Wang GH, Juan LR, Zhang TJ, Teng MX, Liu YL, Wang YD. Prioritization of disease microRNAs through a human phenome-microRNAome network, Bmc Systems Biology, 2010, 4 Suppl 1, S2.Jiang QH, Hao YY, Wang GH, Zhang TJ, Wang YD. Weighted network-based inference of human microRNA-disease associations. The 5th International Conference on Frontier of Computer Science and Technology - Workshop on Bioinformatics and System Biology. 2010. 431-435Jiang QH, Wang GH, Wang YD. An approach for prioritizing disease-related microRNAs based on genomic data integration. The 3rd International Conference on BioMedical Engineering and Informatics. 2010. 2270-22742009 Jiang QH, Wang YD, Hao YY, Juan LR, Teng MX, Zhang XJ, Li MM, Wang GH, Liu YL. miR2Disease: a manually curated database for microRNA deregulation in human disease. Nucleic Acids Res．2009，37: D98-104现承担课程
生物信息学（授课对象：生命学院三年级本科生）生物信息技术（授课对象：生命学院硕士一年级）本课程主要介绍生物信息学基本概念及特点、常用生物数据库、基因组浏览器、Linux系统常用命令、R语言编程、基因芯片原理及数据分析、新一代DNA测序技术原理及其数据分析、生物信息学热点问题分析等内容。通过本课程的讲授，旨在使学生了解生命科学学术前沿技术及研究问题、培养学生运用所学的数据分析技术解决生命科学中前沿问题的能力，为今后从事生命科学研究奠定基础。
研究生培养
2017年招生：博士生2名，硕士生3名，欢迎计算机、数学、生物、生物信息学等相关专业的同学报考。
蒋庆华教授欢迎所有喜欢阅读顶级期刊论文，希望在哈工大生命学院攻读硕士学位并以发表学术论文为乐趣的有志青年加入他的研究团队，有意者可致信qhjiang at hit.edu.cn。
对于没有任何编程及信息技术基础的学生，蒋庆华教授会用大约半年的时间与他们一起学习经典实用的编程语言（R、Python等），指导学生掌握基本的统计与数据挖掘方法，发现并跟踪最前沿的生命科学热点问题，并用所学的编程技能及信息学方法解决这些问题。
蒋庆华教授鼓励他的学生将科研作为毕生的追求和事业，支持他的学生在毕业后继续攻读博士学位（出国攻博或公派出国进行二年的博士生联合培养）。
