李宗金（南开教授）的个人简介
李宗金 ，男 ，南开大学医学院教授。主要从事干细胞治疗，人胚胎干细胞的分化，组织工程，肿瘤干细胞及分子影像学的研究
教育经历
博士后斯坦福大学2005-2009
博士中国协和医科大学2000-2005
学士白求恩医科大学1989-1994
工作经历
2009-至今南开大学医学院
2005-2009斯坦福大学放射系，分子影像中心
学术兼职
1．2009-至今Circulation Research杂志审稿人
2. 2009-至今 Peer Reviewer for the American Heart Association
3. 2010 Stem Cells International客座主编
4. 2010-至今 自然科学基金面上项目评审
5. 2010-2012 American Journal of Nuclear Medicine and Molecular Imaging编委
6. 2912-2014 中国组织工程研究杂志执行编委
7. 2012- 高等学校博士学科点专项科研基金网络评审专家
8. 2012- 教育部学位中心“省市优秀硕士学位论文评选”通讯评议评审专家
研究方向
主要从事干细胞治疗，人胚胎干细胞的分化，组织工程，肿瘤干细胞及分子影像学的研究，在国际上率先应用胚胎干细胞来源的内皮细胞用于缺血性心脏病的治疗。同时，应用纳米脂质体联合分子影像技术靶向肿瘤干细胞的研究也得到了较高的评价。包括在Nature Methods, Circulation, J Am Coll Cardiol, Stem Cells, Caner Res，Stroke, Biomaterials等杂志发表论文40余篇，其中SCI论文36篇，被引用超过800次。
参与了3部专著的撰写，申请了2项发明专利。研究工作先后获得多项奖励，包括：2007年美国血管生物学学会优秀青年科学家奖、2008年美国心脏病学会优秀青年科学家奖、2009年斯坦福大学心血管研究所优秀青年科学家奖、Mitzi and William Blahd, MD 启动基金第一名等。
1) 国家重大科学研究计划项目973（项目编号：2011CB964903） 2011-2015
经费：￥4,620,000，为研究骨干，经费来源：科技部。研究课题“多潜能干细胞特异性诱导分化及其表观遗传学调控在治疗糖尿病中的应用基础研究”，子课题“在体胰岛组织和肾上皮组织干细胞归巢、复制、分化的示踪新技术与新方法”。研究内容: 建立 MSC和ESC在小动物的分子影像监测技术，利用分子影像技术，评价 MSC和ESC在糖尿病和肾功能衰竭中的作用; 建立大动物模型，引进 PET，MRI等分子影像技术，监测其在大动物体内功能的改变。
2)国家自然科学基金（项目批准号：31071308） 2011-2013
经费：￥370，000，项目主持人，经费来源：国家自然科学基金委。研究课题“非病毒微载体重编程心脏干细胞为诱导多能干细胞(iPSC)的研究”。
3) 2010年度高等学校博士学科点专项科研基金.经费：￥60,000，为研究骨干，经费来源：教育部。研究课题“非病毒微载体重编程心脏干细胞为诱导多能干细胞的研究”。
4）天津应用基础与前沿技术研究计划（自然科学基金）重点项目 2012-2014
经费：￥200，000，项目主持人，经费来源：天津科委。
5）国家教育部留学回国人员科研启动金
经费：￥35，000，项目主持人，经费来源：教育部。
专利
1. 具有肿瘤靶向、体内示踪和治疗作用的脂质体药物组合物及制备方法，第一发明人
2. 具有肿瘤靶向、体内示踪和治疗作用的人胚胎干细胞来源的内皮细胞, 第一发明人
讲授课程
1．病理生理学
2．干细胞生物学
荣誉奖励
2006 美国心脏学会(AHA)墙报前10名
2006-2007斯坦福大学博士后基金
2007 美国血管生物学会Jay D. Coffman优秀青年科学家奖
2008 第57届美国心脏病学会(ACC)优秀青年科学家奖
2008 ACCF/Bristol-Myers Squibb Travel Award, 美国心脏病学会(ACC)
2008 斯坦福大学医学院心血管病研究所，优秀青年科学家奖
2008 国际干细胞学会 (ISSCR) Travel Award
2008 Mitzi and William Blahd, MD 启动基金第一名, 美国核医学会
2009 Journal of Cellular Biochemistry, 2009年106卷第2期封面文章
2010 发表在 Stroke, 2010, 41(3):516-23 的文章被F1000选中.
2012南开大学第四届良师益友提名奖
主要贡献
1. Su W, Wang L, Zhou M, Tong L, Liu Z, Hu S, Liu F, Liu Y, Yan F, Kong D, Han Z, WuJC, Xiang R, Li Z*. Human Embryonic Stem Cell-derived Endothelial Cells as Cellular Delivery Vehicles for Targeting Therapy of Breast Cancer. Submitted
2. Jia X, Xie X, Feng G, YaoX, Lü H, Mao L, Zhao Q, Che Y, Han Z, XuY, Li Z*, Kong D*. Bone marrow-derived cells can acquire renal stem cells properties and ameliorate ischemia-reperfusion induced acute renal injury. BMC Nephrology. 2012 in press. (IF, 2.2)
3. Daadi MM, Hu S, Klausner J, Li Z, Sofilos M, Sun G, Wu JC, Steinberg GK. Imaging Neural Stem Cell Graft-Induced Structural Repair in Stroke. Cell Transplantation. 2012 in press. (IF, 6.2)
4. Lu D, Chen S, Tan X, Li N, Liu C, Li Z, Liu Z, Stupack DG, Reisfeld RA, Xiang R. Fra-1 Promotes Breast Cancer Chemosensitivity by Driving Cancer Stem Cells from Dormancy. Cancer Res, 2012, 72(14): 3451-6.Link (IF, 8.2)
5. Wang L, Su W, Liu Z, Zhou M, Chen S, Chen Y, Lu D, Liu Y, Yan F, Zheng Y, Han Z, Kong D, WuJC, Xiang R*, Li Z*. CD44 Antibody Targeted Liposomes for Molecular Imaging and Therapy of Hepatocellular Carcinoma. Biomaterials. 2012, 33(20): 5107-5114Link(IF, 7.8)
6. Wang L, Chen S, Zhang M, Chen Y, Su W, Liu Y, Lu D, Li S, Yang Y, Li Z, Qu P, Hu H, Xiang R. Legumain Serves as a Biomarker for the Diagnosis and Prognosis of Human Ovarian Cancer. J of Cell Biochem. 2012, 113(8): 2679-86. Link(IF, 3.1)
7. Zhou M, Wang L, Su W, Tong L, Liu Z, Liu Y, Yan F, Zheng Y, Zhao H, Xiang R*, Li Z*. Assessment of Therapeutic Efficacy of Liposomal Nanoparticles Mediated Gene Delivery by Molecular Imaging for Cancer Therapy. J Biomed Nanotechnol. 2012, 8(5): 742-750. Link(IF, 4.2)
8. Feng G, Cui J, Zheng Y, Han Z, Xu Y*,Li Z*. Identification, Characterization and Biological Significance of Very Small Embryonic-Like Stem Cells (VSELs) in Regenerative Medicine. Histol Histopathol. 2012, 27(7): 827-833. PMID: 22648539 Link. (IF, 2.5)
9. Zhang J, Jia X, Xu Z, Ding F, Zhou X, Fu H, Liu Y, Ou L, Li Z, Kong D. Improved Mesenchymal Stem Cell Survival in Ischemic Heart Through Electroacupuncture. Chin J Integr Med. 2012, DOI: 10.1007/s11655-012-1101-3. Link. (IF, 0.799)
10.Zhang Z, Yin J, Zhang C, Liang N, Bai N, Chang A, Liu Y, Li Z, Tan X, Li N, Lv D, Xiang R, Tian Y, Liu C. Activating transcription factor 4 increases chemotherapeutics resistance of human hepatocellular carcinoma. Cancer Biology & Therapy, 2012, 13(6) 435-442. Link(IF, 2.9)
11. Hu S, Huang M, Nguyen P, Gong Y, Li Z, Jia F, Lan F, Liu J, Nag D, Robbins RC, Wu JC. Novel MicroRNA Pro-survival Cocktail for Improving Engraftment and Function of Cardiac Progenitor Cell Transplantation. Circulation. 2011, 124: S27-S34. Link (IF, 14.8) (Top 3 advances in AHA Basic Cardiovascular Sciences in 2011)
12. Li Z, Hu S, Ghosh Z, Han Z, Wu JC. Functional Characterization and Expression Profiling of Human Induced Pluripotent Stem Cell- and Embryonic Stem Cell-Derived Endothelial Cells. Stem Cells Dev. 2011, 20(10): 1701-1710. Link(IF, 4.8)
13. Su W, Zhou M, Zheng Y, Fan Y, Han Z, Kong D, Zhao RC, Wu JC, Xiang R*, Li Z*. Bioluminescence reporter gene imaging characterize human embryonic stem cell-derived teratoma formation. J Cell Biochem. 2011, 112: 840u2013848. Link. (IF, 3.1)
14. Wang Y, Wang Yanming, Wang L, Che Y, Li Z*, Kong D*. Preparation and evaluation of magnetic nanoparticles for cell labeling. Journal of Nanoscience and Nanotechnology. 2011, 11: 3749-3756. Link(IF, 1.9)
15.Xie X, Hiona A, Lee A, Cao F, Huang M, Li Z, Cherry A, Pei X, Wu JC. Effects of Long Term Culture on Human Embryonic Stem Cell Aging. Stem Cells Dev. 2011; 20(1): 127-38. Link (IF, 4.8)
16. S, Huang M, Li Z, Jia F, Ghosh Z, Lijkwan M, Sun N, Fasanaro P, Wang X, Martelli R, Robbins RC, Wu JC. MicroRNA-210 as a Novel Therapy for Treatment of Ischemic Heart Disease. Circulation. 2010, 122:S124-S131. Link. (IF, 14.8)
17.Wilson KD, Sun N, Huang M, Zhang WY, Lee AJ, Li Z, Wang SX, Wu JC. Effects of Ionizing Radiation on Self Renewal and Pluripotency of Human Embryonic Stem Cells. Cancer Research. 2010, 70(13): 5539-48. Link(IF, 8.2)
18.Huang NF, Niiyama H, Peter C, De A, Natkunam Y, Fleissner FA, Li Z, Rollins M, Wu JC, Gambhir SS, Cooke JP. Embryonic Stem Cell-Derived Endothelial Cells Incorporate into the Ischemic Hindlimb and Restore Perfusion. Arteriosclerosis, Thrombosis, and Vascular Biology. 2010, 30:915-922. Link (IF, 7.2)
19.Jia F, Wilson KD, Sun N, Gupta DM, Huang M, Li Z, Kay MA, Longaker MT, Wu JC. A Simple Non-viral Minicircle Vector for Deriving Human iPS Cells. Nature Methods. 2010, 7(3): 197-199. Link. (IF, 20.7)
20.DaadiDM, DavisA, Arac A, Li Z, MaagAL, Batnagar R, SunG, WuJC, Steinberg GK. Human Neural Stem Cell Grafts Modify Microglial Response and Enhance Axonal Sprouting In Neonatal Hypoxic-Ischemic Brain Injury. Stroke. 2010, 41(3): 516-23.Link (IF, 7.0) (selected by F1000)
21. Wilson KD, Smith B, Kraft D, Jia F, Xie X, Huang M, Hoyt G, Chu P, Robbins RC, Weissman IL, Gambhir SS, Wu JC. Functional and Transcriptional Characterization of Human Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Myocardial Infarction. PLoS ONE. 2009, 4(12): e8443. Link(IF, 4.4)
22.J, Huang NF, Wilson KD, Velotta JB, Huang M, Li Z, Robbins RR, Cooke JP, Wu JC. nAChRs Mediate Human Embryonic Stem Cell-Derived Endothelial Cells: Proliferation, Apoptosis, and Angiogenesis. PLoS ONE. 2009, 4(9): e7040. Link (IF, 4.4)
23.Huang M, Chen ZY, Jia F, Li Z, Kay MA, Wu JC. Novel minicircle vector for cell based gene therapy in murine myocardial infarction. Circulation. 2009, 120:S230-S237 Link(IF, 14.8)
24.Daadi DM, Li Z, Arac A, GrueterBA, Sofilos M, Malenka RC, Wu JC, Steinberg GK. Molecular and Magnetic Resonance Imaging of Human Embryonic Stem Cell-Derived Neural Stem Cell Grafts in Ischemic Rat Brain. Molecular Therapy. 2009, 17(7): 1282u20131291.Link. (IF, 7.1)
25.Lee A, Huang M, Chung J, Chu P, Yang P, Rosenberg J, Robbins RC, Wu JC. Imaging Survival and Function of Transplanted Cardiac Stem Cells. Journal of the American College of Cardiology. 2009, 53(14):1229u201340. Link (IF,14.3)
26, Han Z, Wu JC*. Transplantation of Human Embryonic Stem Cell-Derived Endothelial Cells for Vascular Diseases. J of Cell Biochem. 2009, 106:194-199. (Journal cover, invited review) Link(IF, 3.5)
27.Xie X, Chan KS, Cao F, Hang M, Li Z, Lee A, Weissman I, Wu JC. Imaging of STAT3 Signaling Pathway During Mouse Embryonic Stem Cell Differentiation. Stem Cell and Development. 2009; 18(2): 205-14. Link(IF, 4.8)
28.Huang M, Chan D, Jia F, Xie X, Li Z, Robbins RC, Chen X, Giaccia A, Wu JC. Short Hairpin RNA Interference Therapy for Ischemic Heart Disease. Circulation.2008; 118: s226-233. Link(IF, 14.8)
29.#Wilson KD, #Li Z, Wager R, Yue P, Tsao P, Nestorova G, Huang M, Hirschberg D, Yock PG, Quertermous D, Wu JC. Transcriptome alteration in the diabetic heart by rosiglitazone: Implications for cardiovascular mortality. PLoS ONE. 2008, 3(7): e2609. (#Co-first author) Link(IF, 4.4)
30. Suzuki Y, Huang M, Cao F, Xie X, Connolly AJ, Yang PC, Wu JC. Comparison of reporter gene and iron particle labeling for tracking fate of human embryonic stem cells and differentiated endothelial cells in living subjects. Stem Cells. 2008, 26(4): 864-873. Link(IF, 7.9)
31 Wu JC, Sheikh AY, Kraft D, Cao F, Xie XY, Patel M, Gambhir SS, Robbins RC, Cooke JP, Wu JC. Differentiation, survival, and function of embryonic stem cell derived endothelial cells for ischemic heart disease. Circulation.2007; 116: I46-I54.Link (IF, 14.4)
32.Xie X, Cao F, Sheikh AY, Li Z, Connolly AJ, Pei X, Li RK, Robbins RC, Wu JC. Genetic modification of embryonic stem cells with VEGF enhances cell survival and improves cardiac function. Cloning and Stem Cells. 2007; 9(4): 553-567 Link(IF, 2.9)
33.Cao F, Drukker M, Lin S, Sheikh AY, Xie X, Li Z, Connolly AJ, Weissman IL, Wu JC.. Molecular imaging of embryonic stem cell misbehavior and suicide gene ablation. Cloning and Stem Cells. 2007; 9(1): 107-17. Link(IF, 2.9)
34.Lin S, Xie X, Patel MR, Yang YH, Li Z, Cao F, Gheysens O, Zhang Y, Gambhir SS, Rao JH, Wu JC. Quantum dot imaging for embryonic stem cells. BMC Biotechnol. 2007; 7(1): 67 Link (Featured in Nanowerk). (IF, 2.9)
35.Chang GY, Cao F, Krishnan M, Huang M, Li Z, Xie X, Sheikh AY, Hoyt G, Robbins RC, Hsiai T, Schneider MD, Wu JC. Positron emission tomography imaging of conditional gene activation in the heart. J Mol Cell Cardiol. 2007; 43(1):18-26. (Journal cover) Link(IF, 5.5)
著作:
1. Yizhou Zheng, Deling Kong and Zongjin Li* (2011). Non-invasive Imaging of Human Embryonic Stem Cells Derived Endothelial Cells Using Reporter Genes, Methodological Advances in the Culture, Manipulation and Utilization of Embryonic Stem Cells for Basic and Practical Applications, Craig Atwood (Ed.), ISBN: 978-953-307-197-8, InTech, (*correspondence author) Link
2. Hu S, Lavinghousez P, Li Z, Wu JC (2011). Differentiation of endothelial cells from hES cells and hiPS cells, Human Embryonic and Induced Pluripotent Stem Cells, Ye, Kaiming; Jin, Sha (Eds.) ISBN 978-1-61779-266-3, Humana Press. Link
3. Tong L, Zhao H, He Z, Li Z (2012). Current Perspectives on Molecular Imaging for Tracking Stem Cell Therapy "Medical Imaging in Clinical Practice", Erondo OF (Eds) ISBN InTech.
