李宏业（暨大教授）的个人简介
李宏业，江苏淮安人，男，教授，博士生导师，主要研究方向：1）海洋微藻生物技术；2）微藻脂类代谢机理及生物能源研发；3）微藻高附加值生物活性物质合成途径；4）微藻藻华。围绕微藻生物活性物质开展代谢机理的系列研究，包括功能基因组学及基因表达调控、高附加值生物活性物质及生物毒素的生物合成途径、基于代谢工程及生物制造推动资源高值化利用。
人物经历
博士学位 2003香港大学; 硕士学位 1997 中科院华南植物所及微生物所; 学士学位1993 扬州大学。
2008.10起任职于暨南大学生命科学与技术学院，教授; 2007u20132008, 香港大学生物科学学院，Croucher助理教授; 2003u20132007, 香港大学及香港中文大学，博士后研究员; 1993u20131998, 中科院华南植物所及微生物所，研究实习员、助理研究员。
中国海洋湖沼学会海洋生物技术分会理事、中国藻业协会工作指导委员会委员、中国植物生理与分子生物学学会能源植物专业委员会委员、FrontiersinMarineScience (IF3.1)等SCI期刊编委。
研究方向
1）海洋微藻生物技术；2）微藻脂类代谢机理及生物能源研发；3）微藻高附加值生物活性物质合成途径；4）微藻藻华。
主要贡献
近 5 年作为通讯作者及第一单位，在Science子刊Science Advances、Metabolic Engineering、Environmental Microbiology、Biotechnology for Biofuels、Marine Biotechnology 等重要SCI期刊发表论文30余篇，其中SCI一区及二区期刊各12篇；获授权专利5件；研究成果产生了广泛影响，多篇论文被 ScienceDirect 等评为高阅读量文章，入选 ESI 高被引论文。在主要国内外学术会议上做了多次主题报告。主持成果获教育部高等学校科学研究优秀成果奖自然科学奖二等奖、广东省第四届南粤科技创新优秀学术论文一等奖、中国藻类学会优论文二等奖等奖项。
近期代表性论文如下：
Li DW, Balamurugan S, Yang YF, Zheng JW, Huang D, Zou LG, Yang WD, Liu JS, Guan YF, Li HY. Transcriptional regulation of microalgae for concurrent lipid overproduction and secretion. Science Advances. 2019, 5: eaau3795.
Wang X, Dong HP, Wei W, Balamurugan S, Yang WD, Liu JS, Li HY. Dual expression ofplastidial GPAT1 andLPAT1 regulates triacylglycerol production andthefatty acid profile inPhaeodactylum tricornutum. Biotechnology for Biofuels. 2018. 11:318.
Yang YF, Li DW, Chen TT, Hao TB, Balamurugan S, Yang WD, Liu JS, Li HY.Overproduction of Bioactive Algal Chrysolaminarin by the Critical Carbon Flux Regulator Phosphoglucomutase. Biotechnology Journal. 2018. e1800220.
Da-Wei Li, Wei-Hong Xie, Ting-Bin Hao, Jia-Xi Cai, Tian-Bao Zhou, Srinivasan Balamurugan, Wei-Dong Yang, Jie-Sheng Liu, Hong-Ye Li. Constitutive and Chloroplast Targeted Expression of Acetyl-CoA Carboxylase in Oleaginous Microalgae Elevates Fatty Acid Biosynthesis. Marine Biotechnology. 2018. 20(5): 566-572.
Wang X, Wei W, Li NJ, Yuan W, Ding Y, Yang WD, Liu JS, Balamurugan S, Li HY. Heterogeneous expression of human PNPLA3 triggers algal lipid accumulation and lipid droplet enlargement. Algal Research. 2018, 31: 276-281.
Balamurugan S, Wang X, Wang HL, An CJ, Li H, Li DW, Yang WD, Liu JS, Li HY. Occurrence of plastidial triacylglycerol synthesis and the potential regulatory role of AGPAT in the model diatom Phaeodactylum tricornutum. Biotechnol Biofuels. 2017;10:97.
Xue J, Balamurugan S, Li DW, Liu YH, Zeng H, Wang L, Yang WD, Liu JS, Li HY. Glucose-6-phosphate dehydrogenase as a target for highly efficient fatty acid biosynthesis in microalgae by enhancing NADPH supply. Metab Eng. 2017. 41, 212u2013221.
Zheng JW, Li DW, Lu Y, Chen J, Liang JJ, Zhang L, Yang WD, Liu JS, Lu SH, Li HY. Molecular exploration of algal interaction between the diatom Phaeodactylum tricornutum and the dinoflagellate Alexandrium tamarense. Algal Research. 2016. 17: 132u2013141.
Niu YF, Wang X, Hu DX, Balamurugan S, Li DW, Yang WD, Liu JS, Li HY. Molecular characterization of a glycerol-3-phosphate acyltransferase reveals key features essential for triacylglycerol production in Phaeodactylum tricornutum. Biotechnology for Biofuels. 2016. 9:60.
Xue J, Niu YF, Huang T, Yang WD, Liu JS, Li HY. Genetic improvement of a microalga Phaeodactylum tricornutum for boosting neutral lipid accumulation. Metabolic Engineering. 2015. 27(1):1-9.
WangX,LiuYH,HuDX,BalamuruganS,LuY,YangWD,LiuJS,LiHY.Identification of a putative patatin-like phospholipase domain-containing protein3(PNPLA3) ortholog involved in lipid metabolism in microalga Phaeodactylum tricornutum, Algal Research,2015(12):274-279.
YangZK,ZhengJW,NiuYF,yangWD,LiuJS,LiHY.Systems-level analysis of metabolic responses of metabolic responses of the diatom Phaeodactylum tricornutum to phosphorus stress. Environmental Microbiology. 2014.16(6):1793-1807
Xie WH, ZhuCC,ZhangNS,LiDW,YangWD,LiuJS,LiHY. Construction of novel chloroplast expression vector and development of high efficient and economical transformation system for diatom Phaeodactylum tricornutum. Marine Biotechnology.2014.16:538-546
YangZK,NiuYF,MaYH,JiaoXue,ZhangMH,YangWD,LiuJS,LuSH,GuanY,LiHY.Molecular and cellular mechanisms of neutral lipid accumulation in diatom following nitrogen deprivation. Biotechnology for Biofuels. 2013.6:67
