李根喜的个人简介
李根喜，男，1965年 2月生，山东省嘉祥县人。
1984～1994年，在南京大学化学系高分子化学、分析化学专业学习，分别获学士、硕士和博士学位，1994年6 月在该校生化系作博士后，1996年5月出站并留生化系任教，1996～2000年为副教授，2001年为教授，2002年为博导，其中，1998～2000年分别在德国慕尼黑大学生物系、日本东北大学药学部、美国哈佛大学医学院生化与分子药学系作访问学者。1999年任生化系系主任。主要从事蛋白质电子传递、界面行为及其与生物小分子、纳米材料相互作用的研究。科研成果“蛋白质和酶的电荷传递及界面行为与电化学分析法的研究”在 1999年1月获教育部科技进步三等奖。
现任上海大学生命科学学院院长、教授、博士生导师，中国生物化学与分子生物学会蛋白质专业委员会常务委员、副秘书长，中国仪器仪表学会化学传感器专业委员会委员。
担任编委的主要期刊：
1. International Journal of Molecular Sciences副主编 2005.5-2006.2；国际顾问编委
2006.3～
2. American Journal of Biochemistry and Biotechnology地区编委2005.1 ～
3. Asian Chemistry Letters国际顾问编委2004. 1 ～
4. 中国生物化学与分子生物学报编委2004. 1 ～
5. Biochemistry and Molecular Biology Education编委 2008.1 ～
李根喜 - 研究方向
本小组主要是采用电化学方法，并结合其他一些生物学、化学手段，通过对电极表面进行功能修饰，对蛋白质等生物大分子进行分子改造，以研究生物分子的电子传递和界面行为，并对分子识别机制、信号传递过程、生物传感技术、信息分子功能等热点问题进行探讨，对蛋白质功能和结构研究的新途径进行探索，建立生物分子测定的新方法、新技术，发展新型生物传感器件，以期对单分子、单细胞和生物活体进行实时、无创伤研究。
近期正致力于以下方面课题的研究：
1. 蛋白质的电子传递、电化学及界面行为。
2.
蛋白质功能与结构的电化学研究。
3.
纳米生物学。
4.
分子识别、组装及相互作用。
5.
新型第三代生物传感器的研制。
6.
生物信号分子研究及相关信号传导机制探索。
已发表论文160余篇。近期代表论著如下：
李根喜 - 近期主要专业论文
1 Nandi Zhou, Jing Wang, Ting Chen, Zhiguo Yu, Genxi Li
Enlargement of gold nanoparticles on the surface of self-assembled monolayer modified
electrode: A mode in biosensor design
Anal. Chem, 2006, 78, 5227～5230
2 Yinxi Huang, Lei Liu, Chang Shi, Junyi Huang, and Genxi Li
Electrochemical interrogation of the effect of Ca2+ on cardiolipin-cytochrome c interaction
Biochimica et Biophysica Acta - General Subjects, 2006, 1760: 1827～1830
3 Hui Zhou, Lei Liu, Kun Yin, Shanli Liu, Genxi Li
Electrochemical investigation on the catalytic ability of tyrosinase with the effect of nano titanium dioxide
Electrochem. Comm., 2006, 8: 1168～1172
4 Xiaofeng Zheng, Anyue Chen, Tomonori Hoshi, Jun-ichi Anzai, Genxi Li
Electrochemical studies of (D)-epigallocatechin gallate and its interaction with DNA
Anal Bioanal Chem, 2006, 386: 1913～1919
5 Rongwu Yang, Xinjian Liu, Zhiqiang Zhu, Shanli Liu, Genxi Li
Enhanced electron transfer and catalytic activity of cyanocobalamin with β-cyclodextrin
Sensor Lett, 2006, 4: 416～418
6 Rongwu Yang, Ge Gao, Ting Liu, Shanli Liu, Genxi Li
Enhanced ability of hemoglobin to carry oxygen by salidroside
Electrochem. Comm., 2007, 9: 94～96
7 Guifang Chen, Jing Zhao, Xinjian Liu, Ge Gao, Junyi Huang, Genxi Li
Electrochemical sensing DNA damage with nano- titanium dioxide and repair with a medicinal herb species resveratrol
Journal of Biotechnology, 2007, 127: 653～656
8 Xiaoli Zhu, Ishida Yuri, Xin Gan, Iwao Suzuki, and Genxi Li
Electrochemical study of the effect of nano zinc oxide on microperoxidase and its application to more sensitive hydrogen peroxide biosensor preparation
Biosensors and Bioelectronics, 2007, 22: 1600～1604
9 Jing Chen, Guifang Chen, Dong Li, Jianbo Jia, Genxi Li
Electroanalysis of ethanol with a glass carbon electrode co-modified with liver tissue homogenate and carbon nanotubes
Electroanalysis, 2007, 19: 813～815
10 Jing Wang, Zhiqiang Liang, Lihua Wang, Chunhai Fan, Genxi Li
Electron transfer reactivity and catalytical activity of structurally rigidized hemoglobin
Sensors and Actuators B, 2007, 125: 17～21
11 Jing Zhao, Xiaofeng Zheng, Xin Zhang, Junyi Huang, and Genxi Li
Electrochemical Studies of camptothecin and its interaction with human serum albumin
International Journal of Molecular Sciences, 2007, 8: 42～50
12 Han Xiao, Jing Wang, Guifang Chen, and Genxi Li
Electrochemical sensing of self-disassociation of PKA upon activation by cAMP
Langmuir, 2007, 23: 3506～3508
13 Han Xiao, Hui Zhou, Guifang Chen, Shanli Liu, Genxi Li
Electrochemical studies of inducible nitric oxide synthase modulated by binding of calmodulin in Ca2+-free and -bound forms
Journal of Proteome Research, 2007, 6: 1426～1429
14 Guifang Chen, Xiang Ma, Xin Zhang, Junyi Huang, Genxi Li
An electrochemical study of myoglobin entrapped in three kinds of films
Sensor Lett, 2007, 5: 463～466
15 Lei Liu, Xiaoli Zhu, Dongmei Zhang, Junyi Huang, and Genxi Li
An electrochemical method to detect folate receptor positive tumor cells
Electrochem. Comm., 2007, 9: 2547～2550
16 Jing Wang, Nandi Zhou, Zhiqiang Zhu, Junyi Huang, Genxi Li
Detection of flavonoids and assay of their antioxidant activity based on enlargement of gold nanoparticles
Anal Bioanal Chem, 2007, 388: 1199～1205
17 Xiaoli Zhu, Qianlu Yang, Junyi Huang, Iwao Suzuki, Genxi Li
Colorimetric study of the interaction between gold nanoparticles and a series of amino acids
J. Nanosci. Nanotechnol., 2008, 8: 353～357
18 Xiaoli Zhu, Wenjun Zhang, Han Xiao, Junyi Huang, and Genxi Li
Electrochemical study of a hemin-DNA complex and its activity as a ligand binder
Electrochimica Acta, 2008, 53: 4407～4413
19 Junyi Huang, Dongmei Zhang, Wei Xing, Xiang Ma, Yanxia Yin, Qun Wei, Genxi Li
An approach to assay the enzymatic activity of calcineurin and the inhibitory
effect of zinc ion
Anal. Biochem., 2008, 375: 385～387
20 Guifang Chen, Xiang Ma, Fanben Meng, Genxi Li
The electron transfer reactivity of kaempferol and its interaction with amino acid residues
Bioelectrochemistry, 2008, 72: 169～173
21 Guifang Chen, Xiaoli Zhu, Fanben Meng, Zhiguo Yu, and Genxi Li
Apoferritin as a bionanomaterial to facilitate the electron transfer reactivity of hemoglobin and the catalytic activity towards hydrogen peroxide
Bioelectrochemistry, 2008, 72: 77～80
22 Han Xiao, Ting Liu, Nandi Zhou, Zhiguo Yu, and Genxi Li
Electron transfer reactivity and catalytic activity of choline oxidase in
Didodecyldimethylammonium bromide film and its application for sensitive
choline monitoring
Sensor Lett., 2008, 6: 209～212
23 Jing Zhao, Wenying Meng, Peng Miao, Zhiguo Yu, Genxi Li
Photodynamic effect of hypericin on the conformation and catalytic activity of hemoglobin
Int. J. Mol. Sci., 2008, 9: 145～153
24 Xiaoqiang Liang, Guifang Chen, Xin Zhang, Shanli Liu, Genxi Li
Study of UVA irradiation on hemoglobin in the presence of NADH
Journal of Photochemistry and Photobiology B: Biology, 2008, 90: 53～56
25 Junyi Huang, Lin Chen, Xin Zhang, Shanli Liu, Genxi Li
Electrochemical studies of ion-channel behavior of annexin V in phosphatidylcholine
bilayer membranes
Electrochem. Comm., 2008, 10: 451～454
主要著作：
1. Genxi Li, “Protein-based Voltammetric Sensors”; in “Encyclopedia of Sensors”, Edited by Craig A. Grimes, Elizabeth C. Dickey and Michael V. Pishko, American Scientific Publisher, 2006, Volume 8, pp. 301-314.
2. Genxi Li, “Protein-based biosensors using nanomaterials”; in “Nanotechnologies for Life Sciences”, Edited by Challa Kumar, Wiley-VCH, 2006, volume 8, “Nanomaterials for Biosensors”, 2007, pp. 278-310.
