李国梁（博士）的个人简介
1984年生，山东泰安人，博士，副教授，硕士研究生导师
工作经历
2003.09－2007.07青岛农业大学，获得学士学位。
2007.09－2010.07中国科学院西北高原生物研究所，获得硕士学位。
2010.09－2012.07中国科学院西北高原生物研究所，获得博士学位。
2012.07－ 今 在曲阜师范大学山东省绿色天然产物及医药中间体开发重点实验室、山东省生命有机分析重点实验室从事教学与科研工作.，主要讲授本科生课程《天然药物化学》，《天然产物与新药开发》及研究生课程《生物化学》。
研究方向
食品分析方向：设计并合成高灵敏度荧光探针分子，结合改性剂用于高效液相色谱中低含量化合物的荧光识别，并结合HPLC-MS 或CE 实现了对食品中毒性成分及功能成分的高灵敏、高选择性检测。
天然产物中活性成分研究：主要从事药食同源食品中活性成分分离、纯化及鉴定，并利用建立方法进行活性成分进行精确定量，对得到的活性单体进行体外活性研究。
已发表研究论文40余篇，其中SCI收录36 篇，申请国家发明专利2项。主持国家级、省级、校级科研项目4项，参与国家自然基金项目5项，省部级项目3项。
已发表研究论文40余篇，其中SCI收录38 篇，申请国家发明专利3项。担任国际学术杂志《Current Nutrition & Food Science》, 《Journal of Food, Nutrition and Dietetics》及《Journal of Experimental Food Chemistry》编委。
同时担任《Biosensors and Bioelectronics》；《Journal of Agricultural and Food Chemistry》；《Food Research International》；《Food Chemistry》；《Food & Function》；《Journal of Separation Science》；《Talanta》；《Biomedical Chromatography》；《Analytical method》；《RSC Advances》等SCI杂志审稿专家。
科研项目
1，石榴皮中三萜酸成分及其降糖活性研究；2014年1月-2016年12月，国家自然基金委青年基金项目，主持,进行中（NO 31301595）
2，藏药獐牙菜中三萜酸的准确分析及其指纹图谱建立；2010年1月-2012年12月：中国科学院科技创新类项目,主持,结题，（NO36）
3，石榴皮中三萜酸成分及其降血糖活性研究；2014年1月-2016年12月，曲阜师范大学科技计划项目,主持,进行中（编号xkj201302）,
4，基于柱前荧光标记―分散液液微萃取技术的水产品中生物胺快速、高灵敏HPLC检测方法研究及其应用，2014年,6月-2016年12月；广东省水产品加工与安全重点实验室资助，主持，进行中（NO：GDPKLAPPS1401）
5,基于宏基因组文库的新壳聚糖酶筛选及计算机辅助合理化设计；2014年1月-2016年12月，国家自然基金委项目, 排名第二, 进行中（NO 31301438）
近年发表论文情况：(*为通讯作者)
[1]Guoliang Li*,Weiheng Kong,Meizhao, et al, A fluorescence resonance energy transfer (FRET) based “Turn-On” nanofluorescence sensor using a nitrogen-doped carbon dot-hexagonal cobalt oxyhydroxidenanosheet architecture and application to α-glucosidase inhibitor screening，Biosensors and Bioelectronics,2016. doi:10.1016/j.bios.2015.12.094 (IF=6.48)
[2]Guoliang Li*,Huili Fu, Xuejie Chen, et al, Facile and Sensitive Fluorescence Sensing of Alkaline Phosphatase in Vitro and Living Cells with Highly Photoluminescent Carbon Dots Based on Inner Filter Effect,Analytical Chemistry,2016, DOI: 10.1021/acs.analchem.5b04193 (IF=5.636)
[3]Guoliang Li,Jinmao You, Cuihua Song, YouruiSuo, Development of a New HPLC Method with Precolumn Fluorescent Derivatization for Rapid, Selective and Sensitive Detection of Triterpenic Acids in Fruits,Journal of Agricultural and Food Chemistry,2011,59 (7), 2972u20132979.(SCI收录)
[4]Guoliang Li,Jinmao You, YouruiSuo, Cuihua Song, Zhiwei Sun, A developed pre-column derivatization method for the determination of free fatty acids in edible oils by reversed-phase HPLC with fluorescence detection and its application to Lyciumbarbarum seed oil,Food Chemistry, 2011，125(4) 1365-1372.(SCI收录)
[5]Guoliang Li,Yanyan Cui, Jinmao You, Yourui Suo, Determination of trace amino acids by a selective and sensitive pre-column derivatization method using HPLC-FLD-MS/MS,Amino acids,2011,40(4), 1185-1193.(SCI收录)
[6]Guoliang Li,Xiaolong Zhang, Jinmao You, Zhiwei Sun, YouruiSuo, Highly sensitive and selective pre-column derivatization high-performance liquid chromatography approach for rapid determination of triterpenes acids and application to Swertia species,AnalyticaChimicaActa,2011, 688(2)208-218.(SCI收录)
[7]Guoliang Li,Junyou Shi,Zhiwei Sun, You Jinmao,Yongjun Liu, Supercritical CO2cell breaking extraction of Lyciumbarbarum seed oil and determination of its chemical composition by HPLC/APCI/MS and antioxidant activity.LWT-Food Science and Technology,2011,44(4), 1172-1178.(SCI收录)
[8]Li GL，Dong, L., Wang, A., Wang, W., Hu, N., & You, J.. Simultaneous determination of biogenic amines and estrogens in foodstuff by an improved HPLC method combining with fluorescence labeling.LWT-Food Science and Technology, 2014,55(1), 355-361.(SCI收录)
[9]Guoliang Li,Zhiwei Sun, Jinmao You, Supercritical CO2oil extraction from Chinese star anise seed and simultaneous compositional analysis using HPLC by fluorescence detection and online atmospheric CI-MS identification.Journal of the Science of Food and Agriculture,2010, 90(11):1905-1913.(SCI收录)
[10]Guoliang Li,Sun, Zhiwei, Xia, Lian,Jinmao You, Optimization of red pepper seed oil extraction using supercritical CO2and analysis of the composition by reversed-phase HPLC-FLD-MS/MS.International Journal of Food Science & Technology, 2011, 46(1):44-51.(SCI收录)
[11]Guoliang Li,Guang Chen, Liu, Jinmao You. A sensitive and selective hplc-fld method with fluorescent labeling for simultaneous detection of bile acid and free fatty acid in human serum [J].Journal of Chromatography B, 2012(859)191-195(SCI收录)
[12]Guoliang Li,Zhiwei Sun, Cuihua Song, Jinmao You. A sensitive fluorescence reagent for amino acids determination in Saussurea involucrate and Artemisia capillarisThunb using highu2010performance liquid chromatography with fluorescence detection and identification with mass spectroscopy/electrospray ionization sourceBiomed. Chromatogr.2011:6(689u2013696).(SCI收录)
[13]Guoliang Li,Cuihua Song, Jinmao You, Composition Analysis of Free Fatty Acids from Swertia Species by a Novel Pre-column Fluorescence Labelling Method Using HPLC-FLD[J],Journal of the American Oil Chemists’ Society, 2012,89(4) 585-595(SCI收录)
[14]Hongliang Wu,Guoliang Li*,Shucheng Liu, ZhongyinJia, Qiulong Zhang and Jinmao You*; Simultaneous determination of seven biogenic amines in foodstuff samples using one-step fluorescence labeling and dispersive liquid-liquid microextraction followed by HPLC-FLD and method optimization using response surface methodology[J],Food Analytical Methods,DOI: 10.1007/s12161-014-9943-2(SCI收录)
[15]Wenli Wang,Guoliang Li*,ZhongyinJi, Na Hu, Jinmao You*,A novel method for trace aldehyde determination in foodstuffs based on fluorescence labeling by HPLC with fluorescence detection and mass spectrometric identification[J],Food Analytical Methods,2014, 7(7): 1546-1556(SCI收录)
[16]Guoliang Li*, Shucheng Liu, Zhiwei Sun, Lian Xia, Guang Chen, Jinmao You*, A simple and sensitive HPLC method based on precolumn fluorescence labeling for multiple classes of plant growth regulator determination in food samples[J],Food Chemistry,. 2015, 170: 123-130.(SCI收录)
[17]Aihong Wang,Guoliang Li*,Jinmao You*, A new fluorescent derivatization reagent and its application to free fatty acid analysis in pomegranate samples using HPLC with fluorescence detection [J],Journal of Separation Science,2013,36(24):3853-9(SCI收录)
[18] Hongliang Wu,Guoliang Li*, Shucheng Liu and Jinmao You* Simultaneous determination of six triterpenic acids in some Chinese medicinal herbs using ultrasound-assisted dispersive liquid-liquid microextraction and high-performance liquid chromatography with fluorescence detection[J],Journal of Pharmaceutical and Biomedical Analysis, doi:10.1016/j.jpba.2014.10.031(SCI收录)
[19]Li G*, Lu S, Wu H, Chen G, You J*. Determination of multiple phytohormones in fruits by highu2010performance liquid chromatography with fluorescence detection using dispersive liquidu2013liquid microextraction followed by preu2010column fluorescent labeling[J].Journal of separation science,DOI: 10.1002/jssc.201401131(SCI收录)
[20]Guoliang Li*, Chenhong Tang, Jinmao You*,et al, A rapid and sensitive method for semicarbazide screening in foodstuffs by HPLC with fluorescence detection[J],Food Analytical Methods,DOI: 10.1007/s12161-014-0063-9(SCI收录)
[21] Hongliang Wu,Guoliang Li*,Monitoring the contents of six steroidal and phenolic endocrine disrupting chemicals in chicken, fish and aquaculture pond water samples using pre-column derivatization and dispersive liquidu2013liquid microextraction with the aid of experimental design methodology,Food Chemistry,doi:10.1016/j.foodchem.2015.06.059(SCI收录)
[22]Guoliang Li*, Chenhong Tang, Jinmao You，Rapid and sensitive screening of some acidic micronutrients in infant foods by HPLC with fluorescent detector，Journal of the Science of Food and Agriculture，DOI: 10.1002/jsfa.7457(SCI收录)
[23] Cuihua Song, Caiqing Zhang,Guoliang Li，Highly selective and sensitive determination of free and total amino acids in apocynumvenetum l.(luobuma tea) by a developed hplc-fld method coupled with pre-column fluorescent labelling [J].International Journal of Food Sciences and Nutrition,2012,63:170-177(SCI收录)
[24] Junyou Shi,Guoliang Li,Rui Zhang, JieZheng, YouruiSuo, A VALIDATED HPLC-DAD METHOD FOR IDENTIFYING AND DETERMINING THE BIOACTIVE COMPONENTS OF TWO KINDS OF LUOBUMA,Journal of Liquid Chromatography & Related Technologies, 2011, 34(7), 537-547.(SCI收录)
[25] YinfengXie,Guoliang Li,Jinmao You, A Novel Labeling Reagent of 2-(12-Benzoacridin-5-(12H)-yl)- acetohydrazide for Determination of Saturated and Unsaturated Fatty Acids in Traditional Chinese Herbs by HPLC-APCI-MS,Chromatograpia, DOI: 10.1007/s10337-012-2226-4(SCI收录)
[26] Junyou Shi,Guoliang Li,Honglun Wang, JieZheng, YouruiSuo, Oneu2010step Separation of Three Flavonoids from Poacynumhendersonii by Highu2010speed Counte current Chromatography,Phytochemical analysis,2011,22(5),450-454.(SCI收录)
[27] Jing Nianhua., Shi Junyou,Li Guoliang, Jinmao You. Determination of fatty acids from mushrooms using high performance liquid chromatography with fluorescence detection and online mass spectrometry [J].Food Research International, 2012,48(1) 155u2013163(SCI收录)
[28] Chen, G., Li, J., Sun, Z., Zhang, S.,Li, G.L,Song, C., Suo, Y., & You, J. (2014). Rapid and sensitive ultrasonic-assisted derivatisationmicroextraction (UDME) technique for bitter taste-free amino acids (FAA) study by HPLCu2013FLD.Food Chemistry, 143, 97-105(SCI收录)
[29] Chen, G., Li, J., Zhang, S., Song, C.,Li, G.L,Sun, Z., Suo, Y., & You, J. (2012). A sensitive and efficient method to systematically detect two biophenols in medicinal herb, herbal products and rat plasma based on thorough study of derivatization and its convenient application to pharmacokinetics with semi-automated device.Journal Of Chromatography A,1249, 190-200.(SCI收录)
[30] Nianhua Jing，Guoliang Li,Jinmao You, QUANTITATIVE ANALYSIS OF FATTY ACIDS FROM SNOWLOTUS (SAUSSUREA) SPECIES USING HPLC WITH FLUORESCENCE DETECTION AND ATMOSPHERIC CHEMICAL IONIZATION-MASS SPECTROMETRY,Journal of Liquid Chromatography & Related Technologies,2012, (13)1882-1894(SCI收录)
[31] Lian Xia, Jinmao You,Guoliang Li,ZhiweiSun,YouruiSuo, Compositional and Antioxidant Activity Analysis of Zanthoxylumbungeanum Seed Oil Obtained by Supercritical CO2 Fluid Extraction,Journal of the American Oil Chemists’ Society,2011 (88)23u201332.(SCI收录)
[32] Lian Xia, Zhi Wei Sun,Guo Liang Li,You Rui Suo, A sensitive analytical method for the component monosaccharides of the polysaccharides from a Tibetan herb Potentilla anserine L. by capillary zone electrophoresis with UV detector,European Food Research and Technology,2010,230, (5), 715-722(SCI收录)
